منابع مشابه
Low penetrance in the long-QT syndrome: clinical impact.
BACKGROUND It is still currently held that most patients affected by the long-QT syndrome (LQTS) show QT interval prolongation or clinical symptoms. This is reflected by the assumption in linkage studies of a penetrance of 90%. We had previously suggested that a larger-than-anticipated number of LQTS patients might be affected without showing clinical signs. We have now exploited the availabili...
متن کاملKCNE1 and KCNE2 variants in Patients with Long QT Syndrome
Introduction: Long QT syndrome (LQTS) is a type of ventricular arrhythmia characterized by prolonged QT intervals on electrocardiogram or delay in ventricular repolarization and it can lead to syncope, seizure and sudden cardiac death. Here, KCNE1 and KCNE2 variants are studied among Iranian affected families with this syndrome. Materials and Methods: Fifty patients referring to Rajaei Cardiov...
متن کاملThe Long QT Syndrome
Introduction The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the "primary cardiac arrhythmias" or "cardiac ion channelopathies". The study of inherited LQTS has prov...
متن کامل[The long QT interval syndrome].
The syndrome of long QT interval frequently follows to syncope or a sudden cardiac death on the basis of originated polymorphic ventricular tachycardia of the "torsade de pointes" type. The prolongation of the QT interval in the hereditary form is based on mutation of the genes responsible for the formation of sodium and potassium channels. The authors analyze the occurrence, clinical findings,...
متن کاملLong QT Syndrome
Background. Erythromycin is known to prolong ventricular repolarization and has been associated with the occurrence of torsades de pointes. In this study, we have investigated potential mechanisms in vivo and in vitro for induction of an acquired long QT syndrome by erythromycin. Methods and Results. Ventricular electrograms and endocardial monophasic action potentials were recorded in anesthet...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.99.4.529